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Mutat Res. 2012 Jul 1;735(1-2):46-50. doi: 10.1016/j.mrfmmm.2012.05.004. Epub 2012 Jun 4.

SOS induction and mutagenesis by dnaQ missense alleles in wild type cells.

Author information

1
University of Medicine and Dentistry of New Jersey - New Jersey Medical School, Department of Microbiology and Molecular Genetics, 225 Warren Street, ICPH-E450V, Newark NJ 07101-1709, United States.

Abstract

Mistranslation leads to elevated mutagenesis and replication arrest, both of which are hypothesized to result from the presence of mixed populations of wild type and mistranslated versions of DNA polymerase III subunit proteins. Consistent with this possibility, expression of missense alleles of dnaQ (which codes for the proofreading subunit ɛ) in wild type (dnaQ+) cells is shown to lead to SOS induction as well as mutagenesis. Exposure to sublethal concentrations of streptomycin, an aminoglycoside antibiotic known to promote mistranslation, also leads to SOS induction.

PMID:
22677460
PMCID:
PMC3389301
DOI:
10.1016/j.mrfmmm.2012.05.004
[Indexed for MEDLINE]
Free PMC Article

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