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Allergy Asthma Clin Immunol. 2012 Jun 7;8(1):9. doi: 10.1186/1710-1492-8-9.

Predictive value of IgE/IgG4 antibody ratio in children with egg allergy.

Author information

1
Department of Pediatrics, Kansai Medical University, Fumizonocho 10-15, Moriguchi, Osaka, 570-8506, Japan. taniuchi@takii.kmu.ac.jp.

Abstract

BACKGROUND:

The aim of this study was to investigate the role of specific IgG4 antibodies to hen's egg white and determine their utility as a marker for the outcome of oral challenge test in children sensitized to hen's egg

METHODS:

The hen's egg oral food challenge test was performed in 105 sensitized children without atopic dermatitis, and the titers of egg white-specific immunoglobulin G4 (IgG4) and immunoglobulin E (IgE) antibodies were measured. To set the cut-off values of IgG4, IgE, and the IgE/IgG4 ratio for predicting positive results in oral challenges, receiver operating characteristic curves were plotted and the area under the curves (AUC) were calculated.

RESULTS:

Sixty-four of 105 oral challenges with whole eggs were assessed as positive. The AUC for IgE, IgG4, and IgE/IgG4 for the prediction of positive results were 0.609, 0.724, and 0.847, respectively. Thus, the IgE/IgG4 ratio generated significantly higher specificity, sensitivity, positive predictive value (%), and negative predictive value (%) than the individual IgE and IgG4. The negative predictive value of the IgE/IgG4 ratio was 90% at a value of 1.

CONCLUSIONS:

We have demonstrated that the egg white-specific serum IgE/IgG4 ratio is important for predicting reactivity to egg during food challenges.

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