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J Virol. 2012 Aug;86(16):8884-9. doi: 10.1128/JVI.00358-12. Epub 2012 Jun 6.

A vesiculovirus showing a steepened transcription gradient and dominant trans-repression of virus transcription.

Author information

1
Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.

Abstract

Vesicular stomatitis virus (VSV) is a prototype nonsegmented, negative-sense virus used to examine viral functions of a broad family of viruses, including human pathogens. Here we demonstrate that S(2) VSV, an isolate with a small plaque phenotype compared to other Indiana strain viruses, has a transcription defect resulting in an altered pattern and rapid decline of transcription. The S(2) VSV transcription gradient is dominant over the wild-type transcription in a coinfection. This is the first characterization of an altered gradient of transcription not dependent on RNA template sequence or host response and may provide insight into new approaches to viral attenuation.

PMID:
22674990
PMCID:
PMC3421768
DOI:
10.1128/JVI.00358-12
[Indexed for MEDLINE]
Free PMC Article
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