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Sci Transl Med. 2012 Jun 6;4(137):137rv7. doi: 10.1126/scitranslmed.3004184.

Microbiota, disease, and back to health: a metastable journey.

Author information

1
Gastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. rblumberg@partners.org

Abstract

Alterations in the composition of the commensal microbiota have been observed in many complex diseases. Understanding the basis for these changes, how they relate to disease risk or activity, and the mechanisms by which the symbiotic state of colonization resistance and host homeostasis is restored is critical for future therapies aimed at manipulating the microbiota.

PMID:
22674557
PMCID:
PMC5020897
DOI:
10.1126/scitranslmed.3004184
[Indexed for MEDLINE]
Free PMC Article

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