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Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6900-3. doi: 10.1002/anie.201201337. Epub 2012 Jun 5.

Mechanism of the prokaryotic transmembrane disulfide reduction pathway and its in vitro reconstitution from purified components.

Author information

1
Institute for Molecular Biology and Biophysics, ETH Zurich, Switzerland. malojcic@fas.harvard.edu

Abstract

Making your (Dsb) connection: the redox pathway bringing reducing equivalents from bacterial cytoplasm, across the inner membrane, to the three reductive Dsb pathways in the otherwise oxidizing periplasm (see scheme; TR=thioredoxin reductase, Trx=thioredoxin) is reconstituted from purified components. Transfer of reducing equivalents across the membrane is demonstrated and underlying mechanistic details are revealed.

PMID:
22674494
DOI:
10.1002/anie.201201337
[Indexed for MEDLINE]

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