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FEBS Lett. 2012 May 21;586(10):1472-9. doi: 10.1016/j.febslet.2012.03.068. Epub 2012 Apr 18.

MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.

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1
Department of Geriatrics, Zhejiang Provincial People's Hospital, Hangzhou, PR China.

Abstract

Cellular cholesterol levels are tightly regulated and represent a balance of cholesterol uptake, endogenous synthesis and efflux. Although the classic transcriptional regulations of cholesterol metabolism by liver X receptors (LXRs) have been well studied, the potential effects of LXR-responsive microRNAs (miRNAs) still need to be unveiled. Here, we describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux. These findings have not only figured out an alternative mechanism for LXR regulation, but also provided a potential therapeutic target for cholesterol metabolic disorders.

PMID:
22673513
DOI:
10.1016/j.febslet.2012.03.068
[Indexed for MEDLINE]
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