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Trends Microbiol. 2012 Sep;20(9):411-8. doi: 10.1016/j.tim.2012.05.002. Epub 2012 Jun 4.

The ParA/MinD family puts things in their place.

Author information

1
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA. jlutkenh@kumc.edu

Abstract

Bacteria must segregate their DNA and position a septum to grow and divide. In many bacteria, MinD is involved in spatial regulation of the cytokinetic Z ring, and ParAs are involved in chromosome and plasmid segregation. The use of the MinD/ParA family to provide positional information for spatial organization continues to expand with the recognition that orphan ParAs are required for segregating cytoplasmic protein clusters and the polar localization of chemotaxis proteins, conjugative transfer machinery, type IV pili, and cellulose synthesis. Also, some bacteria lacking MinD use orphan ParAs to regulate cell division. Positioning of MinD/ParA proteins is either due to self-organization on a surface or reliance on a landmark protein that functions as a molecular beacon.

PMID:
22672910
PMCID:
PMC3436946
DOI:
10.1016/j.tim.2012.05.002
[Indexed for MEDLINE]
Free PMC Article

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