Format

Send to

Choose Destination
See comment in PubMed Commons below
Biomarkers. 2012 Sep;17(6):483-9. doi: 10.3109/1354750X.2012.691553. Epub 2012 Jun 7.

Biomarkers intersect with the exposome.

Author information

1
Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720-7356, USA. srappaport@berkeley.edu

Abstract

The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.

PMID:
22672124
PMCID:
PMC4763608
DOI:
10.3109/1354750X.2012.691553
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center