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Ann N Y Acad Sci. 2012 Jun;1257:133-41. doi: 10.1111/j.1749-6632.2012.06537.x.

ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis.

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Center of Research and Advanced Studies, Cinvestav, Department of Physiology, Biophysics and Neuroscience, Mexico DF, Mexico.


ZO-2 is a membrane-associated guanylate kinase homologue (MAGUK) tight protein associated with the cytoplasmic surface of tight junctions. Here, we describe how ZO-2 is a multidomain molecule that binds to a variety of cell signaling proteins, to the actin cytoskeleton, and to gap, tight, and adherens junction proteins. In sparse cultures, ZO-2 is present at the nucleus and associates with molecules active in gene transcription and pre-mRNA processing. ZO-2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.

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