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Nat Rev Microbiol. 2012 Jun 6;10(7):449-58. doi: 10.1038/nrmicro2800.

Replication-transcription conflicts in bacteria.

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1
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Abstract

DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major advances have been made in understanding how cells avoid conflicts between replication and transcription and how such conflicts are resolved when they do occur. In this Review, we summarize these findings, which shed light on the significance of the problem and on how bacterial cells deal with unwanted encounters between the replication and transcription machineries.

PMID:
22669220
PMCID:
PMC3467967
DOI:
10.1038/nrmicro2800
[Indexed for MEDLINE]
Free PMC Article
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