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Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Apr;113(4):500-4. doi: 10.1016/j.oooo.2011.09.007.

Clinical evaluation of allicin oral adhesive tablets in the treatment of recurrent aphthous ulceration.

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1
Department of Stomatology, the First People's Hospital of Chenzhou, Chenzhou, China. jxw0927@yahoo.com.cn

Abstract

OBJECTIVE:

We investigated the effectiveness and safety of topical application of 5 mg allicin adhesive tablets in the treatment of minor recurrent aphthous ulcerations (MiRAU).

MATERIAL AND METHODS:

A randomized, double-blinded, placebo-controlled, clinical trial was performed. Tablets containing 5 mg allicin or vehicle only were consecutively applied 4 times per day for 5 days. The size and pain level of ulcers were measured and recorded on days 1, 2, 4, and 6.

RESULTS:

A total of 96 subjects with MiRAU fulfilled the study. Allicin adhesive tablets significantly reduced ulcer size (P < .005, P < .003, P < .001 for days 2, 4, and 6, respectively) and alleviated ulcer pain score (P < .03, P < .001, P < .05 for days 2, 4, and 6, respectively) compared with vehicle tablets. Minor and major adverse reactions were not observed.

CONCLUSIONS:

Allicin adhesive tablets were effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of MiRAU without significant side effects.

PMID:
22668427
DOI:
10.1016/j.oooo.2011.09.007
[Indexed for MEDLINE]
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