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Zhongguo Zhong Yao Za Zhi. 2012 Feb;37(4):505-8.

[Effect of gypenosides on DMN-induced liver fibrosis in rats].

[Article in Chinese]

Author information

1
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Institute of Liver Disease of Shanghai University of Traditional Chinese Medicine, Shanghai 201201, China. fengqin1227@163.com

Abstract

OBJECTIVE:

To study the effect of gypenosides on DMN-induced liver fibrosis in rats.

METHOD:

A rat liver fibrosis model was established by injecting DMN intraperitoneally. Four weeks later, model rats were randomly devided into three groups: the model group, the gypenosides treated group (200 mg x kg(-1)) and the colchicine treated group (0.1 mg x kg(-1)), with 10 specimens for each group. After a 2-week treatment, following parameters were observed: (1) last body weight, weight ratio between liver and spleen; (2) content of liver hydroxyproline (Hyp); (3) activity of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), content of albumin (Alb) and total bilirubin( TBiL) in serum; (4) liver pathology (Sirius red staining and HE staining); (5) activity of liver superoxide dismutase (SOD), glutathione reduced (GSH), glutathione peroxidase (GSH-Px) and content of liver maleic dialdehyde (MDA).

RESULT:

There were classic liver cirrhosis pathological changes in model groups. Compared with the normal group, liver Hyp content, activity of serum ATL, AST, gamma-GT and content of serum TBiL, MDA of model groups significantly increased; content of serum Alb and liver GSH, activity of liver SOD and GSH-Px decreased significantly in model groups. In comparison with the model group, liver cirrhosis remarkable improved in the gypenosides group, content of liver Hyp reduced significantly (P < 0.01), which was equal to the colchicine group. Compared with the model group, liver function parameters improved markedly in the gypenosides group; liver SOD and GSH-Px activities significantly increased; MDA content reduced significantly (P < 0.05).

CONCLUSION:

Gypenosides shows an effect in treating DMN-induced liver fibrosis in rats.

PMID:
22667153
[Indexed for MEDLINE]

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