Format

Send to

Choose Destination
Sci Rep. 2012;2:431. doi: 10.1038/srep00431. Epub 2012 May 30.

High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour.

Author information

1
Dept. Integrative Biology & Physiology, UCLA, Los Angeles, CA 90095, USA.

Abstract

To assess how the shift from a healthy diet rich in omega-3 fatty acids to a diet rich in saturated fatty acid affects the substrates for brain plasticity and function, we used pregnant rats fed with omega-3 supplemented diet from their 2nd day of gestation period as well as their male pups for 12 weeks. Afterwards, the animals were randomly assigned to either a group fed on the same diet or a group fed on a high-fat diet (HFD) rich in saturated fats for 3 weeks. We found that the HFD increased vulnerability for anxiety-like behavior, and that these modifications harmonized with changes in the anxiety-related NPY1 receptor and the reduced levels of BDNF, and its signalling receptor pTrkB, as well as the CREB protein. Brain DHA contents were significantly associated with the levels of anxiety-like behavior in these rats.

PMID:
22666534
PMCID:
PMC3362800
DOI:
10.1038/srep00431
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center