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Mediators Inflamm. 2012;2012:684274. doi: 10.1155/2012/684274. Epub 2012 May 14.

Lipopolysaccharides: from Erinyes to Charites.

Author information

1
Department of Health Sciences, Institute of Microbiology, University "Magna Graecia" of Catanzaro, Via T. Campanella 115, 88100 Catanzaro, Italy.

Abstract

Following the discovery of endotoxins by Richard Pfeiffer, such bacterial product was associated to many severe disorders produced by an overwhelming inflammatory response and often resulting in endotoxic shock and multiple organ failure. However, recent clinical and basic sciences investigations claimed some beneficial roles of typical as well as atypical endotoxins. The aim of this paper is to focus on recent data supporting a beneficial activity of both typical and atypical endotoxins. Such novel perspective looks promising for development of new drugs for prevention and therapy of several human diseases.

PMID:
22665953
PMCID:
PMC3361297
DOI:
10.1155/2012/684274
[Indexed for MEDLINE]
Free PMC Article
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