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Mediators Inflamm. 2012;2012:608249. doi: 10.1155/2012/608249. Epub 2012 May 14.

Usefulness of faecal calprotectin measurement in children with various types of inflammatory bowel disease.

Author information

1
Department of Paediatrics, Medical University of Silesia, Medykow 16, 40-752 Katowice, Poland. mayka101@interia.pl

Abstract

INTRODUCTION:

The aim of the study was to assess the usefulness of the FC measurement in children with various types of IBD and relation to the disease activity.

PATIENTS AND METHODS:

91 patients (49 boys: 53.85% and 42 girls: 46.15%, mean age: 13.38 years, range 6-18 years) were included in the analysis. Patients were divided into the groups: B1-24 children with CD, B2-16 patients with UC, and a group comprising 31 children with other types of colitis; the control group (K) comprised 20 healthy children. FC was assayed by ELISA method, using Phical test (Calpro).

RESULTS:

The mean faecal calprotectin concentrations were higher in children with CD and UC as compared to healthy controls, patients with eosinophilic, lymphocytic, and nonspecific colitis. A positive correlation was observed between FC concentrations and the disease activity (the PCDAI scale, the Truelove-Witts Scale, and the endoscopic Rachmilewitz Index).

CONCLUSION:

It seems that the FC concentrations can be a useful, safe, and noninvasive test in children suspected for IBD, since FC concentration is higher in children with CD and UC than in patients with other inflammatory diseases.

PMID:
22665952
PMCID:
PMC3361316
DOI:
10.1155/2012/608249
[Indexed for MEDLINE]
Free PMC Article

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