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J Exp Med. 2012 Jun 4;209(6):1057-68. doi: 10.1084/jem.20120571.

Neural reflexes in inflammation and immunity.

Author information

1
Department of Women's and Children's Health, Karolinska University Hospital, Karolinska Institutet, S-171 76 Stockholm, Sweden. ulf.andersson@ki.se

Abstract

The mammalian immune system and the nervous system coevolved under the influence of infection and sterile injury. Knowledge of homeostatic mechanisms by which the nervous system controls organ function was originally applied to the cardiovascular, gastrointestinal, musculoskeletal, and other body systems. Development of advanced neurophysiological and immunological techniques recently enabled the study of reflex neural circuits that maintain immunological homeostasis, and are essential for health in mammals. Such reflexes are evolutionarily ancient, dating back to invertebrate nematode worms that possess primitive immune and nervous systems. Failure of these reflex mechanisms in mammals contributes to nonresolving inflammation and disease. It is also possible to target these neural pathways using electrical nerve stimulators and pharmacological agents to hasten the resolution of inflammation and provide therapeutic benefit.

PMID:
22665702
PMCID:
PMC3371736
DOI:
10.1084/jem.20120571
[Indexed for MEDLINE]
Free PMC Article

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