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Yonsei Med J. 2012 Jul 1;53(4):691-700. doi: 10.3349/ymj.2012.53.4.691.

Antidiabetic effects of Corni Fructus extract in streptozotocin-induced diabetic rats.

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1
Department of Biological Engineering, College of Environmental and Chemical Engineering, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, China. dwgao@ysu.edu.cn

Abstract

PURPOSE:

Diabetes is the leading cause of end-stage renal failure. The present study was undertaken to characterize the effects of Corni Fructus on diabetic nephropathy in streptozotocin-induced diabetic rats and their mechanisms.

MATERIALS AND METHODS:

Streptozotocin-diabetic rats were orally administrated with Corni Fructus at a dose of 100, 200 or 400 mg/kg body mass for 40 days.

RESULTS:

Corni Fructus-treated diabetic rats showed significant decreases of blood glucose, urinary protein levels and water consumption. Corni Fructus also reduced serum total cholesterol, total triglyceride and low-density lipoprotein cholesterol levels, and showed a tendency of enhancing high-density lipoprotein cholesterol level. Levels of serum albumin and creatinine in diabetic rats were also significantly reduced by Corni Fructus administration at a dose of 200 and 400 mg/kg body mass compared with non-treated diabetic rats. Corni Fructus increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidose (GSH-px) activities in the kidneys of diabetic rats. Furthermore, Corni Fructus treatment enhanced renal peroxisome proliferator-activated receptor-γ (PPARγ) expression in diabetic rats.

CONCLUSION:

These results demonstrated that Corni Fructus may have the potential to protect the animals from diabetic nephropathy by amelioration of oxidative stress and stimulation of PPARγ expression.

PMID:
22665333
PMCID:
PMC3381479
DOI:
10.3349/ymj.2012.53.4.691
[Indexed for MEDLINE]
Free PMC Article
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