Format

Send to

Choose Destination
Nat Struct Mol Biol. 2012 Jun 5;19(6):568-76. doi: 10.1038/nsmb.2303.

A mechanistic overview of translation initiation in eukaryotes.

Author information

1
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. caitken@jhmi.edu

Abstract

Translation initiation in eukaryotes is a complex and highly regulated process requiring the action of at least 12 protein factors. The pathway is distinguished by the formation of a pre-initiation complex that recruits the 5' end of the mRNA and scans along it to locate the start codon. During the past decade, a combination of genetics, biochemistry and structural studies has begun to illuminate key molecular events in this critical phase of gene expression. Here, we outline our current understanding of eukaryotic translation initiation and discuss important outstanding challenges.

PMID:
22664984
DOI:
10.1038/nsmb.2303
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center