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Nat Struct Mol Biol. 2012 Jun 5;19(6):560-7. doi: 10.1038/nsmb.2313.

One core, two shells: bacterial and eukaryotic ribosomes.

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Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.


Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to have evolved from a common ancestor by addition of proteins and RNA that bestow different functionalities to ribosomes from different domains of life. Recently, structures of the eukaryotic ribosome, determined by X-ray crystallography, have allowed us to compare these structures to previously determined structures of bacterial ribosomes. Here we describe selected bacteria- or eukaryote-specific structural features of the ribosome and discuss the functional implications of some of them.

[Indexed for MEDLINE]

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