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Front Oncol. 2012 May 30;2:46. doi: 10.3389/fonc.2012.00046. eCollection 2012.

Differential Expression of Chemokine Receptors and their Roles in Cancer Imaging.

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Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University Baltimore, MD, USA.

Abstract

Chemokine/chemokine receptor interactions play diverse roles in cell migration and homeostasis. Emerging evidence suggests that cancer cells co-opt chemokine networks for survival, proliferation, immune evasion, and metastasis. Most of the chemokine receptors are reported to be involved in tumor progression. Given their extensive implication in cancer progression, several chemokine receptor/ligand axes are considered as potential therapeutic targets. This review provides a survey of chemokine receptor expression in cancer and evaluates the potential of chemokine receptor imaging as a tool for molecular characterization of cancer.

KEYWORDS:

cancer; chemokine; chemokine receptor; metastasis; molecular imaging

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