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Indian J Psychol Med. 2012 Jan;34(1):85-6. doi: 10.4103/0253-7176.96168.

Successful use of add - on topiramate for antipsychotic - induced weight gain.

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Department of Psychiatry, The Metabolic Clinic in Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.


Antipsychotic induced weight gain is the most common and distressing side effect. This also affects the compliance toward the treatment and hence the prognosis. Non - pharmacological interventions such as exercise and diet modifications alone might not be sufficient most of the times; also ensuring compliance toward this is difficult in patients with psychiatric illness. So, the role of weight - reducing drugs become important. In this case report, we describe the use of low - dose topiramate as a weight - reducing agent, in a patient with a bipolar affective disorder - mania with psychotic symptoms, who had significant risperidone - induced weight gain.


Antipsychotics; bipolar affective disorder; topiramate; weight gain

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