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J Biol Chem. 1990 Dec 25;265(36):22059-62.

Protein structure determination in solution by NMR spectroscopy.

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Institut für Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule-Hönggerberg, Zürich, Switzerland.


The introduction of nuclear magnetic resonance (NMR) spectroscopy as a second method for protein structure determination at atomic resolution, in addition to x-ray diffraction in single crystals, has already led to a significant increase in the number of known protein structures. The NMR method provides data that are in many ways complementary to those obtained from x-ray crystallography and thus promises to widen our view of protein molecules, giving a clearer insight into the relation between structure and function.

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