Format

Send to

Choose Destination
See comment in PubMed Commons below
J Atten Disord. 2014 Nov;18(8):659-70. doi: 10.1177/1087054712446172. Epub 2012 Jun 1.

Reduced neural error signaling in left inferior prefrontal cortex in young adults with ADHD.

Author information

1
University of Ulm, Baden-Württemberg, Germany nenad.vasic@uni-ulm.de.
2
Central Institute of Mental Health, Mannheim, Baden-Württemberg, Germany University of Heidelberg, Baden-Württemberg, Germany.
3
University of Heidelberg, Baden-Württemberg, Germany.
4
University of Tübingen, Baden-Württemberg, Germany.
5
University of Ulm, Baden-Württemberg, Germany.

Abstract

OBJECTIVE:

The neural network involved in inhibition of inappropriate response tendencies shares commonalities with the error-processing network, signaling failure of inhibition. Most studies on error processing in ADHD have been conducted in children using electrophysiological methods.

METHOD:

Using event-related functional magnetic resonance imaging, the authors studied 14 adults with ADHD and 12 group-matched healthy control participants while performing a modified version of a combined Eriksen Flanker-Go/NoGo-task.

RESULTS:

Patients with ADHD demonstrated significantly reduced error signaling in the left inferior frontal gyrus bordering the anterior insular cortex (BA 47), computed from the contrast of unsuccessful minus successful inhibition trials.

CONCLUSION:

Hypoactivation of the left inferior frontal cortex during error signaling might represent a neurofunctional marker of a crucial prerequisite for error processing in adults with ADHD. This possibly indicates a dysfunction of the neural system that operates task-set related representations and monitoring of erroneous performances in service of ensuing posterror processing.

KEYWORDS:

ADHD; error processing; functional magnetic resonance imaging; inferior frontal gyrus; prefrontal cortex

PMID:
22660917
DOI:
10.1177/1087054712446172
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center