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Nat Genet. 2012 Jun 3;44(7):808-11. doi: 10.1038/ng.2309.

Comparative population genomics of maize domestication and improvement.

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1
Department of Plant Sciences, University of California, Davis, California, USA.

Abstract

Domestication and plant breeding are ongoing 10,000-year-old evolutionary experiments that have radically altered wild species to meet human needs. Maize has undergone a particularly striking transformation. Researchers have sought for decades to identify the genes underlying maize evolution, but these efforts have been limited in scope. Here, we report a comprehensive assessment of the evolution of modern maize based on the genome-wide resequencing of 75 wild, landrace and improved maize lines. We find evidence of recovery of diversity after domestication, likely introgression from wild relatives, and evidence for stronger selection during domestication than improvement. We identify a number of genes with stronger signals of selection than those previously shown to underlie major morphological changes. Finally, through transcriptome-wide analysis of gene expression, we find evidence both consistent with removal of cis-acting variation during maize domestication and improvement and suggestive of modern breeding having increased dominance in expression while targeting highly expressed genes.

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PMID:
22660546
PMCID:
PMC5531767
DOI:
10.1038/ng.2309
[Indexed for MEDLINE]
Free PMC Article

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