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Peptides. 2012 Aug;36(2):308-14. doi: 10.1016/j.peptides.2012.05.014. Epub 2012 Jun 1.

Antimicrobial peptides: clinical relevance and therapeutic implications.

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1
Emergency Medicine Department, University of Sao Paulo, Brazil. pinheirofabiano@hotmail.com

Abstract

Antimicrobial peptides (AMPs) are molecules that provide protection against environmental pathogens, acting against a large number of microorganisms, including bacteria, fungi, yeast, virus and others. Two major groups of antimicrobial peptides are found in humans: cathelicidins and defensins. Recently, several studies have furnished information that besides their role in infection diseases, antimicrobial peptides play a role in diseases as diverse as inflammatory disorders, autoimmunity and cancer. Here, we discuss the role of antimicrobial peptides and vitamin D have in such complex diseases and propose their use should be more explored in the diagnosis and treatment of such conditions.

PMID:
22659161
DOI:
10.1016/j.peptides.2012.05.014
[Indexed for MEDLINE]
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