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Curr Opin Virol. 2012 Aug;2(4):459-66. doi: 10.1016/j.coviro.2012.05.004. Epub 2012 Jun 2.

Cancer associated human papillomaviruses.

Author information

1
Division of Infectious Diseases, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Abstract

A small group of human papillomaviruses (HPVs) cause almost all cervical carcinoma and a significant percentage of other anogenital tract and oral carcinoma. Another group of HPVs causes non-melanoma skin cancers in genetically predisposed or immune suppressed patients upon UV exposure. HPV genome replication requires the host cell's DNA synthesis machinery and HPVs encode proteins that maintain differentiated epithelial cells in a replication competent state. The resulting rewiring of cellular signal transduction circuits triggers several innate cellular tumor suppressor responses that HPVs need to inactivate in order to establish persistent and/or productive infections. This review emphasizes this interplay between virus and the infected host cells and points out biological similarities and differences between different groups of HPVs.

PMID:
22658985
PMCID:
PMC3422426
DOI:
10.1016/j.coviro.2012.05.004
[Indexed for MEDLINE]
Free PMC Article

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