Job demands and workplace culture variables associated with work-family conflict stress, in addition to workplace racial bias, were examined for a national sample of 607 African American women in 16 Fortune 1000 companies. Similar to other studies, women in this sample who had dependents were younger, had supervisory responsibilities, and experienced a less positive workplace culture, and those in professional job positions with high job demand were most likely to experience work-family stress. Married women who experienced a more subtle form of workplace racial bias reported more work-family conflict stress. Implications for social work policy, practice, and research are considered.