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J Dent Res. 1979 Sep;58(9):1933-9.

Fluoride inhibition of polymorphonuclear leukocytes.

Abstract

Significant inhibition of PMN metabolic activity by F- occurred at 0.1, 0.5 and 0.0 mM F- for O2- generation, 1-C14 CO2 release labeled glucose and NBT-reduction respectively. This inhibition resulted primarily from F- suppression of nonoxidative glucose metabolism. As the concentration of F- in the O2- generating system increased beyond 10 mM, a rise in production of O2- anion occurred, peaking at 20 mM F-, followed by a rapid decline.

PMID:
226570
DOI:
10.1177/00220345790580092101
[Indexed for MEDLINE]

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