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Int J Cardiol. 2013 Sep 1;167(5):1995-2001. doi: 10.1016/j.ijcard.2012.05.035. Epub 2012 May 30.

Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study.

Author information

1
Hypertension in Africa Research Team, School for Physiology, Nutrition, Consumer Sciences, North-West University, Potchefstroom Campus, Potchefstroom, South Africa. rudolph.schutte@nwu.ac.za

Abstract

BACKGROUND:

Vascular calcification is believed to be due to the conversion of vascular smooth muscle cells into osteoblast-like cells and is associated with mortality. Since hypertension and related mortality in Africans is a concern, we investigated associations between a marker of osteoblastic activity, alkaline phosphatase (ALP), and measures of arterial structure and function in hypertensive African men.

METHODS:

This study included 79 participants. We conducted 24h ambulatory blood pressure and carotid intima-media thickness (cIMT) measurements. cIMT was obtained with an intra-observer variability of 0.04 mm and the cross-sectional wall area (CSWA) was calculated. ALP was measured in serum.

RESULTS:

ALP was within its reference range (101.6 vs. 30.0-120.0 U/L), however cIMT was higher when this group was stratified and compared to gender and age-specific reference values. In univariate and partial regressions, and confirmed with multiple regression analyses, 24h systolic blood pressure (β=0.289, p=0.018), 24h pulse pressure (β=0.387, p=0.002), but not 24h diastolic blood pressure (β=0.073, p=0.58), were positively associated with ALP. In addition, mean cIMT (β=0.322, p=0.006) and CSWA (β=0.285, p=0.013) also correlated positively with ALP after adjusting for significant covariates, and after excluding participants with diabetes, renal dysfunction or a HIV positive status.

CONCLUSION:

Serum alkaline phosphatase is adversely associated with measures of arterial structure and function in hypertensive African men.

KEYWORDS:

Ambulatory blood pressure; Carotid intima–media thickness; Hypertensive African men; Serum alkaline phosphatase

PMID:
22656046
DOI:
10.1016/j.ijcard.2012.05.035
[Indexed for MEDLINE]
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