Format

Send to

Choose Destination
Front Oncol. 2011 Aug 27;1:23. doi: 10.3389/fonc.2011.00023. eCollection 2011.

Targeting apoptosis signaling pathways for anticancer therapy.

Author information

1
Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany.

Abstract

Treatment approaches for cancer, for example chemotherapy, radiotherapy, or immunotherapy, primarily act by inducing cell death in cancer cells. Consequently, the inability to trigger cell death pathways or alternatively, evasion of cancer cells to the induction of cell death pathways can result in resistance of cancers to current treatment protocols. Therefore, in order to overcome treatment resistance a better understanding of the underlying mechanisms that regulate cell death and survival pathways in cancers and in response to cancer therapy is necessary to develop molecular-targeted therapies. This strategy should lead to more effective and individualized treatment strategies that selectively target deregulated signaling pathways in a tumor type- and patient-specific manner.

KEYWORDS:

apoptosis; cancer; signaling

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center