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Open Biochem J. 2012;6:51-5. doi: 10.2174/1874091X01206010051. Epub 2012 May 16.

Effect of peppermint oil on serum lipid peroxidation and hepatic enzymes after immobility stress in mice.

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Department of Biochemistry and Biophysics and Nutrition, Biochemistry and Metabolic Disorder Research Center, Golestan University of Medical Sciences, Golestan province, Gorgan, Iran.


This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic en-zymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. The mice exposed to drink water, 0.9, 27 and 60 mg/kg peppermint oil from the days 1 to 5 for a period of 4 h before and after immobility stress. Serum MDA in-creased in treatment group II, III and IV after immobility stress. There was a significant decrease in ALT in treatment group III and IV after immobility stress. There were also significant decreases in ALP and GGT in treatment group IV af-ter immobility stress. This result may suggest that, MDA level is higher in immobilization stress group than in the un-immobilized animals in serum and this results show that enzyme activities decreased after immobilization stress.


Peppermint oil; hepatic enzymes; immobility stress.; lipid peroxidation

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