Format

Send to

Choose Destination
See comment in PubMed Commons below
ScientificWorldJournal. 2012;2012:379360. doi: 10.1100/2012/379360. Epub 2012 Apr 30.

Antioxidant effect of MnTE-2-PyP on lung in asthma mice model.

Author information

1
Sector of Clinical Immunology and Allergology, Pelven Medical University, 5800 Pleven, Bulgaria. luterzi@mail.bg

Abstract

AIM:

To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model.

MATERIAL AND METHODS:

The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate.

RESULTS:

The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2.

CONCLUSIONS:

The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.

PMID:
22654599
PMCID:
PMC3361234
DOI:
10.1100/2012/379360
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center