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ScientificWorldJournal. 2012;2012:308265. doi: 10.1100/2012/308265. Epub 2012 Apr 30.

CD8+ T cells: GITR matters.

Author information

  • 1Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Università di Perugia, Via del Giochetto, 06100 Perugia, Italy.

Abstract

As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8(+) cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01239134.

PMID:
22654588
PMCID:
PMC3361162
DOI:
10.1100/2012/308265
[PubMed - indexed for MEDLINE]
Free PMC Article
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