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World J Gastroenterol. 2012 May 21;18(19):2377-82. doi: 10.3748/wjg.v18.i19.2377.

Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection.

Author information

1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul 136-705, South Korea. drchunhj@chol.com

Abstract

AIM:

To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations.

METHODS:

The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology.

RESULTS:

The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively).

CONCLUSION:

There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.

KEYWORDS:

Duodenal ulcer; Gastric ulcer; Gastritis; Helicobacter pylori; Sequential therapy; Triple therapy

PMID:
22654429
PMCID:
PMC3353372
DOI:
10.3748/wjg.v18.i19.2377
[Indexed for MEDLINE]
Free PMC Article

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