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Front Biosci (Elite Ed). 2012 Jun 1;4:2442-56.

The role of micronutrients in the diet of HIV-1-infected individuals.

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Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Catania, Italy.


Vitamins, zinc and selenium are important micronutrients that play crucial functions at the cellular and molecular level. Immune response of several different cell types can be modulated by these micronutrients. Deficiency in micronutrients has been extensively reported in HIV-1-infected individuals and further correlated with CD4+ T-cell count, HIV-1 plasma viral load, disease progression and mortality. Supplementation by micronutrients has had controversial effects. Thorough future investigations and trials are certainly needed to strategically plan evidence-based interventions. Here, we review the available data on use of micronutrients during the course of HIV-1 infection.

[Indexed for MEDLINE]

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