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Clin Nutr. 2012 Aug;31(4):448-54. doi: 10.1016/j.clnu.2011.01.003. Epub 2012 May 29.

Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality.

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Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China.



Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT.


RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software.


Data from 19 studies including 47921 participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs.


B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.

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