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Acta Clin Croat. 2011 Dec;50(4):627-31.

Successful treatment of brain ischemia with supplementation therapy in a patient with hyperhomocysteinemia.

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  • 1University Department of Neurology, Ljubljana University Clinical Center, Ljubljana, Slovenia.


The effectiveness of homocysteine-lowering therapy on stroke prevention is still unclear. Although randomized controlled epidemiological trials have yielded mixed findings, a multicenter trial did not show any beneficial effect. Genetic studies are still lacking. Therefore, we report on a female patient with transient ischemic attacks and the thermolabile variant of methylenetetrahydrofolate reductase (TT genotype), who benefited from supplemental therapy for homocysteine lowering.

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