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Case Rep Gastroenterol. 2012 Jan;6(1):205-10. doi: 10.1159/000338740. Epub 2012 Apr 30.

Prolonged survival in a patient with neuroendocrine tumor of the cecum and diffuse peritoneal carcinomatosis.

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Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon (AP-HP and Université Paris VII - Denis Diderot), Clichy, France.


Peritoneal carcinomatosis is a well-known factor of poor prognosis in patients with digestive adenocarcinomas. Peritoneal dissemination may also occur in midgut well-differentiated neuroendocrine tumors, but its influence on survival is ill-defined. We report here the history of a 64-year-old woman who had a neuroendocrine tumor of the cecum with multiple synchronous metastases in the liver and diffuse peritoneal carcinomatosis. She underwent surgical resection of the primary tumor and cytoreduction of liver metastases, and received subsequently chemotherapy and somatostatin analogs. In spite of the widespread extension of the disease, she survived for 13 years and died from a carcinoid heart disease. We discuss the natural history and prognostic factors in patients with midgut well-differentiated neuroendocrine tumors, with a focus on the impact of the peritoneal carcinomatosis.


Digestive neuroendocrine tumors; Dissemination; Peritoneal carcinomatosis; Prognosis; Survival

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