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Pediatr Blood Cancer. 2012 Nov;59(5):780-4. doi: 10.1002/pbc.24214. Epub 2012 May 30.

Current issues and controversies in the classification of pediatric hepatocellular tumors.

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  • 1Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030, USA.


Systematic histopathologic examination of hepatoblastoma specimens from patients enrolled in therapeutic protocols has allowed the identification of clinically relevant histologic subtypes that are being incorporated into risk stratification systems. Genetic and molecular studies have documented recurrent chromosomal abnormalities and aberrant activation of developmental, and oncogenic signaling pathways in hepatoblastoma. Molecular profiling has also identified molecular subclasses and gene signatures that could be used to stratify hepatoblastoma patients. Future international collaboration is needed to develop consensus pathology classifications, and to progressively incorporate genetic and molecular biomarkers into therapeutic pediatric liver tumors protocols.

Copyright © 2012 Wiley Periodicals, Inc.

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