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Pediatr Blood Cancer. 2012 Nov;59(5):934-8. doi: 10.1002/pbc.24103. Epub 2012 Feb 2.

Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon.

Author information

1
Department of Dermatology, Division of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. ychiu@mcw.edu

Abstract

Propranolol is a non-selective beta-adrenergic antagonist successfully used in a case of kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon (KMP). We report 11 patients treated with propranolol for KHE and the related variant tufted angioma (TA), six of whom also had KMP. The varied responses to treatment, with only 36% responding in our series, demonstrate the need for further study of this medication before routine use for these indications.

PMID:
22648868
PMCID:
PMC3528889
DOI:
10.1002/pbc.24103
[Indexed for MEDLINE]
Free PMC Article

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