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Am J Hematol. 2012 Sep;87(9):898-902. doi: 10.1002/ajh.23254. Epub 2012 May 31.

Prothrombin complex concentrates in emergency bleeding disorders.

Author information

1
Division of Hematology, University of Utah Medical Center, Salt Lake City, UT 84132, USA. george.rodgers@hsc.utah.edu

Abstract

The use of prothrombin complex concentrates (PCCs), a heterogeneous combination of coagulation factors and counterbalancing inhibitor components, has broadened in recent years beyond single-factor replacement in conditions such as hemophilia B, to encompass emergency reversal of anticoagulation secondary to oral vitamin K antagonists, ie, warfarin therapy. PCCs also have been studied in other bleeding disorders, such as surgery-related and trauma-related bleeding. This review provides an updated examination of the differences among PCC formulations, their potential role in the management of bleeding disorders, and the primary safety issues affecting their use. Am. J. Hematol. 2012.

PMID:
22648513
DOI:
10.1002/ajh.23254
[Indexed for MEDLINE]
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