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World J Surg Oncol. 2012 May 30;10:98. doi: 10.1186/1477-7819-10-98.

Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood.

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1
General, Visceral und Transplantation Surgery, Hanover Medical School, Carl-Neuberg-Str, 1, 30625, Hannover, Germany.

Abstract

BACKGROUND:

Cases with subcutaneous metastasis of differentiated hepatocellular carcinoma to the abdominal wall without prior seeding as a consequence of local interventions with a negative or normal alpha-fetoprotein level in the serum are extremely rare.

CASE REPORT:

This is the first report of a case with AFP-negative, differentiated hepatocellular carcinoma metastasis to the abdominal wall within a pre-existing subcutaneous lipoma since childhood after antiandrogen therapy with leuprorelin and buserelin acetate for prostate cancer without seeding.

METHODS:

Clinical features including histology, immunohistochemistry, clinical course and surgical approach are presented.

RESULTS:

Histological examination revealed a hepatocellular carcinoma with a trabecular and pseudoglandular growth pattern with moderately atypical hepatocytes with multifocal bile formation within a lipoma. The postoperative course of abdominal wall reconstruction with a monocryl-prolene mesh and a local flap after potentially curative resection was uncomplicated.

DISCUSSION AND CONCLUSION:

It may be that previous antiandrogen treatment for prostate carcinoma contributed to the fact that our patient developed alpha-fetoprotein-negative and androgen receptor-negative subcutaneous abdominal wall metastasis within a pre-existing lipoma since childhood.

PMID:
22647077
PMCID:
PMC3408335
DOI:
10.1186/1477-7819-10-98
[Indexed for MEDLINE]
Free PMC Article
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