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J Renin Angiotensin Aldosterone Syst. 2013 Jun;14(2):181-8. doi: 10.1177/1470320312447652. Epub 2012 May 29.

Association study of angiotensin II type 1 receptor: A1166C (rs5186) polymorphism with coronary heart disease using systematic meta-analysis.

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Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, PR China.


Angiotensin II type 1 receptor (AT1R) mediates the cardiovascular actions of angiotensin II. Growing studies have revealed the underlying association between AT1R-A1166C (rs5186) polymorphism and coronary heart disease (CHD) among the East Asia population.


from these studies remain conflicting. We conducted this meta-analysis to estimate the overall CHD risk of AT1R-A1166C polymorphism regarding the East Asia population. We searched the PubMed, Embase and China National Knowledge Infrastructure (CNKI) databases for all articles within a range of published years from 1995 to 2011. The odds ratio (OR) corresponding to the 95% confidence interval (CI) was used to assess the different associations. The statistical heterogeneity among studies was assessed with the Q-test and I (2) statistics. Up to December 2011, 17 case-control studies, including 2,366 cases and 2,414 controls, were available for our study. The C allele and the AC/CC genotypes were associated with significantly increased risk of CHD (OR = 1.59, 95% CI = 1.22-2.06 for C versus A and OR = 1.57, 95% CI = 1.16-2.13 for AC/CC versus AA, respectively). Our result suggested that AT1R-A1166C polymorphism may be involved in the development of CHD.


AT1R-A1166C; Angiotensin II type 1 receptor; coronary heart disease; meta-analysis; single nucleotide polymorphism

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