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Muscle Nerve. 2012 Jul;46(1):42-50. doi: 10.1002/mus.23276. Epub 2012 May 29.

Diffusion tensor MRI to assess skeletal muscle disruption following eccentric exercise.

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1
Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario.

Abstract

INTRODUCTION:

Structural evidence of exercise-induced muscle disruption has traditionally involved histological analysis of muscle tissue obtained by needle biopsy, however, there are multiple limitations with this technique. Recently, diffusion tensor magnetic resonance imaging (DT-MRI) has been successfully demonstrated to noninvasively assess skeletal muscle abnormalities induced by traumatic injury.

METHODS:

To determine the potential for DT-MRI to detect musculoskeletal changes after a bout of eccentric exercise, 10 healthy men performed 300 eccentric actions on an isokinetic dynamometer. DT-MRI measurements and muscle biopsies from the vastus lateralis were obtained before and 24 h post-exercise.

RESULTS:

Z-band streaming was higher 24 h post-exercise compared with baseline (P < 0.05). The histological indices of damage coincided with changes in DT-MRI parameters of fractional anisotropy (FA) and apparent diffusion coefficient; reflecting altered skeletal muscle geometry (P < 0.05). Z-band streaming quantified per fiber correlated with FA (r = -0.512; P < 0.05).

CONCLUSIONS:

DT-MRI can detect changes in human skeletal muscle structure following eccentric exercise.

PMID:
22644795
DOI:
10.1002/mus.23276
[Indexed for MEDLINE]
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