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Curr Opin Support Palliat Care. 2012 Sep;6(3):348-54. doi: 10.1097/SPC.0b013e3283552d7d.

Atypical femoral fractures: epidemiology, etiology, and patient management.

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1
Materials Science and Engineering, Cornell University, Ithaca, New York, USA.

Abstract

PURPOSE OF REVIEW:

To review the definition, epidemiology, and putative pathophysiology of atypical femoral fractures and propose strategies for the management of patients with atypical fractures as well as patients on long-term bisphosphonates without atypical fractures.

RECENT FINDINGS:

Recent epidemiologic evidence shows that the absolute incidence of atypical femoral fractures is small compared with the incidence of typical hip fractures. However, long-term bisphosphonate use may be an important risk factor for atypical fractures, and minimal additional antifracture benefit has been demonstrated for treatment durations longer than 5 years for patients with postmenopausal osteoporosis. This review gives advice to aid clinicians in the management of patients with incipient or complete atypical fractures.

SUMMARY:

Extremely limited evidence is available for how best to manage patients with atypical fractures. A comprehensive metabolic approach for the management of patients on long-term bisphosphonates will help to prevent oversuppression of bone remodeling that is implicated in the pathogenesis of these fractures.

PMID:
22643705
PMCID:
PMC4556525
DOI:
10.1097/SPC.0b013e3283552d7d
[Indexed for MEDLINE]
Free PMC Article
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