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Cell Res. 2012 Sep;22(9):1315-8. doi: 10.1038/cr.2012.85. Epub 2012 May 29.

Found in translation of mTOR signaling.

Author information

1
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Abstract

The mammalian target of rapamycin (mTOR) protein kinase regulates a wide variety of cellular processes, including protein synthesis, yet the downstream translational program under the control of mTOR is poorly understood. Two recent studies by Hsieh et al. and Thoreen et al. now start to address this issue, and uncover a subset of genes translationally regulated by oncogenic mTOR signaling that may contribute to tumorigenesis.

PMID:
22641373
PMCID:
PMC3434350
DOI:
10.1038/cr.2012.85
[Indexed for MEDLINE]
Free PMC Article

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