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J Cell Biol. 2012 May 28;197(5):575-84. doi: 10.1083/jcb.201201041.

Tracing epithelial stem cells during development, homeostasis, and repair.

Author information

1
Université Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, B-1070 Bruxelles, Belgium.

Abstract

Epithelia ensure many critical functions of the body, including protection against the external environment, nutrition, respiration, and reproduction. Stem cells (SCs) located in the various epithelia ensure the homeostasis and repair of these tissues throughout the lifetime of the animal. Genetic lineage tracing in mice has allowed the labeling of SCs and their progeny. This technique has been instrumental in characterizing the origin and heterogeneity of epithelial SCs, their tissue location, and their differentiation potential under physiological conditions and during tissue regeneration.

PMID:
22641343
PMCID:
PMC3365500
DOI:
10.1083/jcb.201201041
[Indexed for MEDLINE]
Free PMC Article

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