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Mult Scler. 2013 Jan;19(1):120-2. doi: 10.1177/1352458512445302. Epub 2012 May 28.

7 Tesla MRI demonstrates vascular pathology in Balo's concentric sclerosis.

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1
Department of Neurology, University Hospital Giessen and Marburg, Giessen, Germany. martin.berghoff@neuro.med.uni-giessen.de

Abstract

Baló's concentric sclerosis (BCS) is an inflammatory demyelinating disease related to multiple sclerosis; its underlying pathology remains unclear. At 7 T MRI in a 19-year-old female BCS patient, microhaemorrhages and ectatic veins were found in T2 hyperintense regions, features which have not been previously reported in conjunction with BCS, and these findings may support the view that vascular pathology plays a role in BCS. MRS data suggest that neuron loss and lipid turnover still took place months after a remission. Plasma exchange was effective in treating a relapse with severe motor deficits, and the off-label use of natalizumab was successful in maintaining remission in this patient.

PMID:
22641302
DOI:
10.1177/1352458512445302
[Indexed for MEDLINE]
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