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Toxicol Pathol. 2012 Jun;40(4 Suppl):7S-13S. doi: 10.1177/0192623312438738.

International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles.

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1
EPL Northwest, Seattle, Washington 98119, USA. pmann@epl-inc.com

Abstract

The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.

PMID:
22637736
DOI:
10.1177/0192623312438738
[Indexed for MEDLINE]
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