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Nat Genet. 2012 May 27;44(7):770-6. doi: 10.1038/ng.2293.

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Collaborators (306)

MacDonald G, Samuel LM, Ahmad A, Corrie P, Jodrell D, Palmer C, Wilson C, O'Hagan J, Smith D, McDermott R, Walshe J, Cassidy J, McDonald A, Mohammed N, White J, Yosef H, Breathnach O, Grogan L, Thomas R, Eatock M, Henry P, Houston R, Johnston P, Wilson R, Geh I, Danwata F, Hindley A, Susnerwala S, Bradley C, Conn A, Raine A, Twelves C, Falk S, Hopkins K, Tahir S, Dhadda A, Maraveyas A, Sgouros J, Teo M, Ahmad R, Cleator S, Creak A, Lowdell C, Riddle P, Benstead K, Farrugia D, Reed N, Shepherd S, Levine E, Mullamitha S, Saunders M, Valle J, Wilson G, Jones A, Weaver A, Clark PI, Haylock B, Iqbal MI, Myint AS, Smith D, Beesley S, Sevitt T, Nicoll J, Daniel F, Ford V, Talbot T, Butt M, Hamid A, Mack P, Roy R, Osborne R, McKinna F, Alsab H, Basu D, Murray P, Sizer B, Azam FA, Neupane R, Waterston A, Glaholm J, Blesing C, Lowndes S, Medisetti A, Gaya A, Leslie M, Maisey N, Ross P, Dunn G, Al-Salihi O, Wasan S, Palmer C, Tan LT, Dent J, Hofmann U, Joffe JK, Sherwin E, Soomal R, Chakrabarti A, Joseph S, Van der Voet J, Wadd NJ, Wilson D, Anjarwalia S, Hall J, Hughes R, Polychronis A, Scarffe JH, Hill M, James RD, Shah R, Summers J, Hartley A, Carney D, McCaffrey J, Bystricky B, O'Reilly S, Gupta R, Al-Mishlab T, Gidden F, O'Hara R, Stewart J, Ashford R, Glynne-Jones R, Harrison M, Mawdsley S, Barlow H, Tighe M, Walther J, Neal J, Rees C, Bridgewater J, Karp S, McGovern U, Atherton PJ, El-deeb H, Macmillan C, Patel K, Bessell EM, Dickinson PD, Potter V, Jephcott C, McAdam K, Wrigley J, Osborne R, Muthuramalingam S, O'Callaghan A, Bridgewater J, Melcher L, Braconi C, Geh JI, Palmer D, Narayana P, Steven N, Gaya A, Maisey N, Rudman S, Chakraborti P, Kelly K, Macgregor C, Whillis D, Freebairn A, Gildersleve J, Sharif S, Astras G, Hickish T, Beech D, Ellis R, Kulkarni R, Shankland K, Begent R, Mayer A, Meyer T, Strauss S, Hall V, Raj S, Chau I, Cunningham D, Birtle A, Biswas A, Susnerwala S, Wise M, Cummins S, Essapen S, Middleton G, Topham C, Langley R, McKinna F, Webb A, Wilkins M, Iveson TJ, Dhadda A, Hamid A, Askill C, Wagstaff J, Azzabi A, Bateman A, Prejbisz J, Tsang D, Ali N, Jones A, O'Neill P, Cottrill C, Propper D, Lofts FJ, Kennedy J, Anthoney DA, Cooper R, Crellin A, Melcher A, Seymour M, Baughan C, Alexander E, Cleator S, Crown J, Fennelly D, Adab F, Giridharan S, Pedley I, Wright K, Bliss P, Cogill G, Lo N, Toy E, Bridgewater J, Hochhauser D, Ledermann J, Brewster A, Maughan T, Mort D, Mukherjee S, Dobrowsky W, Calvert P, Leonard G, Ahmad R, Ford H, Moody AM, Goriah S, Wilkins M, Clive S, Dawson L, McLean C, Phillips HA, Gopi K, Tomlinson M, Clenton S, Furniss D, Hornbuckle J, Pledge S, Wadsley J, Abbas M, Marshall E, Harper-Wynne C, Barnes A, Kumar S, Vigneswaran V, Farrugia D, Webb A, Gollins S, Falk S, Genton M, Sparrow G, Bale C, Fuller C, Mullard A, Stuart N, Williams R, Keane M, Maughan T, Seymour M, Wilson R, Wasan H, Adams R, Madi A, Cassidy J, Kennedy J, Hodgkinson E, Rogers P, Pope M, Kaplan R, Meade A, Parmar M, Kenny S, Fisher D, Harper L, Mitchell J, Nichols L, Sydes B, Clement L, Kay E, Courtney C, Gallagher M, Murphy C, Thompson L, Beall S, Hassan S, Gracie R, Griffiths G, Mason M, Parker C, Rudd R, Johnson P, Whelan J, Northover J, Brown J, Aapro M, Stout R.

Author information

1
Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council (MRC) Human Genetics Unit, Edinburgh, UK. malcolm.dunlop@hgu.mrc.ac.uk

Abstract

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

PMID:
22634755
PMCID:
PMC4747430
DOI:
10.1038/ng.2293
[Indexed for MEDLINE]
Free PMC Article

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